GenAge entry for TAF1 (Homo sapiens)
Gene name (HAGRID: 180)
- HGNC symbol
- TAF1
- Aliases
- NSCL2; TAFII250; KAT4; DYT3/TAF1; TAF2A; BA2R; CCG1; CCGS; DYT3
- Common name
- TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
- Description
Essential in cell cycle progression, TAF1 is also involved in transcription as part of the TFIID transcription factor together with TBP [891]. There is no direct evidence linking TAF1 to human ageing, but due to TAF1's importance in cell cycle control and its relation with other proteins previously related to ageing, TAF1 might play some role in human ageing.
Cytogenetic information
- Cytogenetic band
- Xq13.1
- Location
- 71,366,239 bp to 71,466,005 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0000209; protein polyubiquitination
GO:0006352; DNA-templated transcription, initiation
GO:0006366; transcription from RNA polymerase II promoter
GO:0006367; transcription initiation from RNA polymerase II promoter
GO:0006368; transcription elongation from RNA polymerase II promoter
GO:0006468; protein phosphorylation
GO:0006974; cellular response to DNA damage stimulus
GO:0007049; cell cycle
GO:0008284; positive regulation of cell proliferation
GO:0010629; negative regulation of gene expression
GO:0010767; regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0016032; viral process
GO:0016573; histone acetylation
GO:0018105; peptidyl-serine phosphorylation
GO:0018107; peptidyl-threonine phosphorylation
GO:0030901; midbrain development
GO:0032092; positive regulation of protein binding
GO:0032436; positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034644; cellular response to UV
GO:0036369; transcription factor catabolic process
GO:0042787; protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0045943; positive regulation of transcription from RNA polymerase I promoter
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO:0046777; protein autophosphorylation
GO:0050821; protein stabilization
GO:0051123; RNA polymerase II transcriptional preinitiation complex assembly
GO:0060260; regulation of transcription initiation from RNA polymerase II promoter
GO:0060261; positive regulation of transcription initiation from RNA polymerase II promoter
GO:0071318; cellular response to ATP
GO:1901796; regulation of signal transduction by p53 class mediator
GO:1902806; regulation of cell cycle G1/S phase transition
GO:1903026; negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
GO:1905524; negative regulation of protein autoubiquitination
GO:2000059; negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000825; positive regulation of androgen receptor activity
Cellular component: GO:0000790; nuclear chromatin
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005667; transcription factor complex
GO:0005669; transcription factor TFIID complex
GO:0005730; nucleolus
GO:0071339; MLL1 complex
Hide GO termsFunction: GO:0000979; RNA polymerase II core promoter sequence-specific DNA binding
GO:0001075; transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly
GO:0001129; RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly
GO:0002039; p53 binding
GO:0003713; transcription coactivator activity
GO:0004402; histone acetyltransferase activity
GO:0004674; protein serine/threonine kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008134; transcription factor binding
GO:0016301; kinase activity
GO:0017025; TBP-class protein binding
GO:0043565; sequence-specific DNA binding
GO:0044212; transcription regulatory region DNA binding
GO:0046982; protein heterodimerization activity
GO:0061631; ubiquitin conjugating enzyme activity
GO:0070577; lysine-acetylated histone binding
GO:1905502; acetyl-CoA binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- TP53, ATM, MYC, FOS, UBE2I, AR, RB1, RELA, JUN, TBP, SIN3A, MAX, MDM2
- STRING interaction network
