GenAge entry for TOP3B (Homo sapiens)
Gene name (HAGRID: 148)
- HGNC symbol
- TOP3B
- Aliases
- Common name
- topoisomerase (DNA) III beta
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
- Description
TOP3B affects the supercoiling of the DNA. Mice lacking TOP3B develop normally but have a shorter lifespan. It is unclear whether these animals age faster [166]. Litter size decreases over time and through successive generations in TOP3B-null mice, probably due to embryonic death [729]. It has been suggested that the age-related phenotype, including lesions in multiple organs as a result of inflammatory responses is due to the development of autoimmunity with age [3659]. A role for TOP3B in human ageing remains to be determined.
Cytogenetic information
- Cytogenetic band
- 22q11.22
- Location
- 21,957,025 bp to 21,982,843 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0006265; DNA topological change
GO:0007059; chromosome segregation
Cellular component: GO:0000793; condensed chromosome
GO:0005634; nucleus
GO:0005829; cytosol
Show all GO termsFunction: GO:0003677; DNA binding
GO:0003916; DNA topoisomerase activity
GO:0003917; DNA topoisomerase type I activity
GO:0005515; protein binding
GO:0044822; poly(A) RNA binding
Protein interactions and network
Retrieve sequences for TOP3B
Homologs in model organisms
- Caenorhabditis elegans
- CELE_Y48C3A.14
- Danio rerio
- top3b
- Drosophila melanogaster
- Top3beta
- Mus musculus
- Top3b
- Rattus norvegicus
- Top3b
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Top3b