GenAge entry for TXN (Homo sapiens)

Gene name (HAGRID: 16)

HGNC symbol
TXN 
Aliases
TRX 
Common name
thioredoxin 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description

TXN plays a role in regulating the cellular redox status. Some evidence also indicates TXN is a growth-suppressor [242]. TXN overexpression in the neurons of flies extended the mean lifespan by 15% [1931]. Its overexpression in mice increases lifespan, but it is not known whether the ageing process is affected [19]. Another study found no overall effects on lifespan of overexpression in mice, although it could be beneficial in the earlier part of life [1959]. As such, its role in human ageing remains unclear.

Cytogenetic information

Cytogenetic band
9q31
Location
110,243,812 bp to 110,256,640 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0000302; response to reactive oxygen species
GO:0006351; transcription, DNA-templated
GO:0006662; glycerol ether metabolic process
GO:0006928; movement of cell or subcellular component
GO:0007165; signal transduction
GO:0007267; cell-cell signaling
GO:0008283; cell proliferation
GO:0009314; response to radiation
GO:0015949; nucleobase-containing small molecule interconversion
GO:0030091; protein repair
And 11 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005829; cytosol
GO:0070062; extracellular exosome
Function: GO:0004791; thioredoxin-disulfide reductase activity
GO:0005515; protein binding
GO:0015035; protein disulfide oxidoreductase activity
GO:0015037; peptide disulfide oxidoreductase activity
GO:0016671; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
GO:0044822; poly(A) RNA binding
GO:0047134; protein-disulfide reductase activity
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, MYC, EGFR, PTEN, NR3C1, NFKB1, EEF2, SOD1, PRDX1, GPX1, MAP3K5, APEX1, RAE1, MLH1, CDKN1A
STRING interaction network
Protein-Protein network diagram for TXN

Retrieve sequences for TXN

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
zgc:56493
Drosophila melanogaster
TrxT
Mus musculus
Txn
Rattus norvegicus
Txn
Saccharomyces cerevisiae
TRX1
Schizosaccharomyces pombe
trx1

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as TrxT
  • A homolog of this gene for Mus musculus is present as Txn1
  • A homolog of this gene for Saccharomyces cerevisiae is present as TRX1
CellAge
  • This gene is present as TXN

Selected references

External links

EPD
HS_TXN
ORF Accession
NM_003329
CDS Accession
NP_003320
OMIM
187700
HPRD
01761
Ensembl
TXN
UniProt/Swiss-Prot
THIO_HUMAN
GeneCards
TXN
Entrez Gene
7295
UniGene
435136
GenAtlas
TXN
Internet
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