GenAge entry for UCP1 (Homo sapiens)

Gene name (HAGRID: 258)

HGNC symbol: UCP1
Aliases: SLC25A7; UCP
Common name: uncoupling protein 1 (mitochondrial, proton carrier)

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description: Mitochondrial uncoupling proteins create proton leaks across the inner mitochondrial membrane to uncouple oxidative phosphorylation from ATP synthesis resulting in energy being dissipated as heat. Mice with skeletal muscle-specific UCP1 expression had increased median survival, decreased adiposity, increased temperature and metabolic rate. The same genetic manipulation in APOE null mice decreased diet-induced atherosclerosis and in agouti yellow mice, a model of obesity, diabetes and hypertension were reversed [1850].

Cytogenetic information

Cytogenetic band: 4q28-q31
Location: 140,559,896 bp to 140,568,805 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0002024; diet induced thermogenesis
GO:0006357; regulation of transcription from RNA polymerase II promoter
GO:0009266; response to temperature stimulus
GO:0015992; proton transport
GO:0031667; response to nutrient levels
GO:0032870; cellular response to hormone stimulus
GO:0034614; cellular response to reactive oxygen species
GO:0050873; brown fat cell differentiation
GO:0071398; cellular response to fatty acid
GO:1903426; regulation of reactive oxygen species biosynthetic process
GO:1990542; mitochondrial transmembrane transport

And 2 more GO terms

Cellular component:

GO:0005739; mitochondrion
GO:0005743; mitochondrial inner membrane
GO:0016021; integral component of membrane

Function:

GO:0017077; oxidative phosphorylation uncoupler activity
GO:0022857; transmembrane transporter activity
GO:0032555; purine ribonucleotide binding
GO:0036041; long-chain fatty acid binding
GO:1901612; cardiolipin binding

Show all GO terms

Protein interactions and network

No interactions in records.

Retrieve sequences for UCP1

ORF: ORF
CDS: CDS

Homologs in model organisms

Mus musculus: Ucp1
Rattus norvegicus: Ucp1

In other databases

LongevityMap

This gene is present as UCP1