GenAge entry for UCP3 (Homo sapiens)

Gene name (HAGRID: 232)

Main reason for selection: Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description: Mitochondrial uncoupling proteins create proton leaks across the inner mitochondrial membrane to uncouple oxidative phosphorylation from ATP synthesis resulting in energy being dissipated as heat. UCP3, whose gene has two splice variants, appears thus to be involved in thermogenesis. Some results from mice suggest that UCP3 might protect against oxidative damage [1449]. Mice overexpressing UCP3 in skeletal muscle are hyperphagic and lean [1456]. UCP3-null mice were normal, though production of reactive oxygen species was increased in mitochondria [1458]. Polymorphisms in the human UCP3 gene could be related to obesity and type 2 diabetes [1459].

Display region using the UCSC Genome Browser (GRCh38/hg38)

Gene Ontology

Process:	GO:0000303; response to superoxide GO:0001666; response to hypoxia GO:0006629; lipid metabolic process GO:0006631; fatty acid metabolic process GO:0006839; mitochondrial transport GO:0007568; aging GO:0007584; response to nutrient GO:0007585; respiratory gaseous exchange GO:0009409; response to cold GO:0014823; response to activity GO:0015992; proton transport
	And 4 more GO terms

Cellular component:

GO:0005739; mitochondrion
GO:0005743; mitochondrial inner membrane
GO:0016021; integral component of membrane

Function:

GO:0005215; transporter activity
GO:0005515; protein binding
GO:0017077; oxidative phosphorylation uncoupler activity

Show all GO terms

LongevityMap