GenAge entry for VEGFA (Homo sapiens)

Gene name (HAGRID: 77)

HGNC symbol: VEGFA
Aliases: VEGF-A; VPF; VEGF
Common name: vascular endothelial growth factor A

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description: VEGFA is a growth factor that been widely implicated in age-related changes [1274], tumorigenesis, and neurogenesis [469]. Mutations in the human VEGFA gene have been associated with type 2 diabetes [1674] and atherosclerosis [1675]. Inactivation of VEGFA in mice results in embryonic lethality [470]. It is unclear whether VEGFA is directly involved in ageing, yet it remains a possible player.

Cytogenetic information

Cytogenetic band: 6p12
Location: 43,770,209 bp to 43,786,486 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001525; angiogenesis
GO:0001541; ovarian follicle development
GO:0001569; branching involved in blood vessel morphogenesis
GO:0001570; vasculogenesis
GO:0001666; response to hypoxia
GO:0001701; in utero embryonic development
GO:0001822; kidney development
GO:0001934; positive regulation of protein phosphorylation
GO:0001938; positive regulation of endothelial cell proliferation
GO:0002042; cell migration involved in sprouting angiogenesis
GO:0002052; positive regulation of neuroblast proliferation
GO:0002053; positive regulation of mesenchymal cell proliferation
GO:0002092; positive regulation of receptor internalization
GO:0002576; platelet degranulation
GO:0002687; positive regulation of leukocyte migration
GO:0003007; heart morphogenesis
GO:0003151; outflow tract morphogenesis
GO:0003169; coronary vein morphogenesis
GO:0007399; nervous system development
GO:0007498; mesoderm development
GO:0007595; lactation
GO:0008284; positive regulation of cell proliferation
GO:0008360; regulation of cell shape
GO:0010595; positive regulation of endothelial cell migration
GO:0010628; positive regulation of gene expression
GO:0030224; monocyte differentiation
GO:0030225; macrophage differentiation
GO:0030324; lung development
GO:0030335; positive regulation of cell migration
GO:0030823; regulation of cGMP metabolic process
GO:0030855; epithelial cell differentiation
GO:0030949; positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031077; post-embryonic camera-type eye development
GO:0031334; positive regulation of protein complex assembly
GO:0031954; positive regulation of protein autophosphorylation
GO:0032147; activation of protein kinase activity
GO:0032793; positive regulation of CREB transcription factor activity
GO:0033138; positive regulation of peptidyl-serine phosphorylation
GO:0035148; tube formation
GO:0035767; endothelial cell chemotaxis
GO:0035924; cellular response to vascular endothelial growth factor stimulus
GO:0036303; lymph vessel morphogenesis
GO:0038033; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:0038091; positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0038190; VEGF-activated neuropilin signaling pathway
GO:0040007; growth
GO:0042462; eye photoreceptor cell development
GO:0042517; positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043066; negative regulation of apoptotic process
GO:0043129; surfactant homeostasis
GO:0043154; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043406; positive regulation of MAP kinase activity
GO:0043536; positive regulation of blood vessel endothelial cell migration
GO:0045766; positive regulation of angiogenesis
GO:0045785; positive regulation of cell adhesion
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO:0048010; vascular endothelial growth factor receptor signaling pathway
GO:0048469; cell maturation
GO:0048593; camera-type eye morphogenesis
GO:0048739; cardiac muscle fiber development
GO:0048754; branching morphogenesis of an epithelial tube
GO:0048842; positive regulation of axon extension involved in axon guidance
GO:0048844; artery morphogenesis
GO:0050679; positive regulation of epithelial cell proliferation
GO:0050731; positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918; positive chemotaxis
GO:0050927; positive regulation of positive chemotaxis
GO:0050930; induction of positive chemotaxis
GO:0051272; positive regulation of cellular component movement
GO:0051781; positive regulation of cell division
GO:0051894; positive regulation of focal adhesion assembly
GO:0060319; primitive erythrocyte differentiation
GO:0060749; mammary gland alveolus development
GO:0060948; cardiac vascular smooth muscle cell development
GO:0060982; coronary artery morphogenesis
GO:0061418; regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0061419; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0071456; cellular response to hypoxia
GO:0071542; dopaminergic neuron differentiation
GO:0071679; commissural neuron axon guidance
GO:0090037; positive regulation of protein kinase C signaling
GO:0090050; positive regulation of cell migration involved in sprouting angiogenesis
GO:0090190; positive regulation of branching involved in ureteric bud morphogenesis
GO:0090259; regulation of retinal ganglion cell axon guidance
GO:1900086; positive regulation of peptidyl-tyrosine autophosphorylation
GO:1900745; positive regulation of p38MAPK cascade
GO:1901727; positive regulation of histone deacetylase activity
GO:1902336; positive regulation of retinal ganglion cell axon guidance
GO:1903572; positive regulation of protein kinase D signaling

Cellular component:

GO:0005576; extracellular region
GO:0005578; proteinaceous extracellular matrix
GO:0005615; extracellular space
GO:0005737; cytoplasm
GO:0009986; cell surface
GO:0016020; membrane
GO:0030141; secretory granule
GO:0031093; platelet alpha granule lumen

Function:

GO:0001968; fibronectin binding
GO:0005125; cytokine activity
GO:0005161; platelet-derived growth factor receptor binding
GO:0005172; vascular endothelial growth factor receptor binding
GO:0005515; protein binding
GO:0008083; growth factor activity
GO:0008201; heparin binding
GO:0042056; chemoattractant activity
GO:0042802; identical protein binding
GO:0042803; protein homodimerization activity
GO:0043183; vascular endothelial growth factor receptor 1 binding
GO:0043184; vascular endothelial growth factor receptor 2 binding
GO:0046982; protein heterodimerization activity
GO:0048018; receptor agonist activity
GO:0050840; extracellular matrix binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: HSP90AA1, VEGFA, FLT1, CTGF
STRING interaction network

Retrieve sequences for VEGFA

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: vegfaa
Mus musculus: Vegfa
Rattus norvegicus: Vegfa

In other databases

LongevityMap

This gene is present as VEGFA

CellAge

This gene is present as VEGFA