GenDR Dietary Restriction Gene Manipulation: SIR2
Gene Information (Entrez Gene ID: 851520)
- Symbol
- SIR2
- Aliases
- MAR1
- Name
- Silent Information Regulator 2
- Organism
- Saccharomyces cerevisiae (AnAge)
- Entrez Gene ID
- 851520
Potential relevance to dietary restriction and ageing
- Observations
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Deletion of SIR2 shortens replicative lifespan by approximately 30%. Integration of a second copy of SIR2 into the wild-type strain leads to an extension of replicative lifespan by around 35% in the W303R strain [200]. 0.5% glucose restriction fails to increase the short lifespan of sir2Delta [2260]. 0.1% glucose restriction extends replicative lifespan of sir2 mutants [2552]. 0.5, 0.1 and 0.05% glucose restriction are able to increase lifespan of sir2;fob1 double mutant to a greater extent than in wild-type. 0.05% glucose restriction further extends replicative lifespan of SIR2 overexpression mutant [2554]. Sir2 blocks extreme chronological lifespan extension as the lack of Sir2 along with DR and/or mutations in the yeast AKT homolog, Sch9, or Ras pathways causes a dramatic chronological lifespan extension (6-fold) [1564].
- References
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In other databases
- GenAge model organism genes
- This gene is present as SIR2
Homologs
- Caenorhabditis elegans
- sir-2.4
External links
- Saccharomyces Genome Database
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- Ensembl
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- Entrez Gene
- ID 851520
- Homologues
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- UniProt
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- Internet
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