Saccharomyces cerevisiae GenDR Dietary Restriction Gene Manipulation: HST2

Gene Information (Entrez Gene ID: 856092)

Symbol
HST2
Name
Homolog of SIR Two (SIR2) 2
Organism
Saccharomyces cerevisiae (AnAge)
Entrez Gene ID
856092

Potential relevance to dietary restriction and ageing

Observations

HST2 overexpression extends replicative lifespan. 0.5% glucose restriction does not increase lifespan of sir2;fob1;hst2 triple mutants [2309]. DR increases lifespan of all four sir2;fob1;hstX(X = sirtuin) triple mutants [2558].

References

    In other databases

    GenAge model organism genes
    • This gene is present as HST2
    • A homolog of this gene for Caenorhabditis elegans is present as sir-2.1
    • A homolog of this gene for Drosophila melanogaster is present as Sirt2
    GenDR gene manipulations
    • A homolog of this gene for Caenorhabditis elegans is present as sir-2.1
    CellAge
    • A homolog of this gene for Homo sapiens is present as SIRT2

    Homologs

    Caenorhabditis elegans
    sir-2.1
    Danio rerio
    sirt3
    Drosophila melanogaster
    Sirt2
    Homo sapiens
    SIRT2
    Mus musculus
    Sirt3
    Rattus norvegicus
    Sirt2
    Schizosaccharomyces pombe
    hst2

    External links

    Saccharomyces Genome Database
    Search
    Ensembl
    Search
    Entrez Gene
    ID 856092
    Homologues
    Search HomoloGene
    UniProt
    Search
    Internet
    Search Google or Search Google Scholar