GenDR Dietary Restriction Gene Manipulation: HST2
Gene Information (Entrez Gene ID: 856092)
- Symbol
- HST2
- Name
- Homolog of SIR Two (SIR2) 2
- Organism
- Saccharomyces cerevisiae (AnAge)
- Entrez Gene ID
- 856092
Potential relevance to dietary restriction and ageing
- Observations
-
HST2 overexpression extends replicative lifespan. 0.5% glucose restriction does not increase lifespan of sir2;fob1;hst2 triple mutants [2309]. DR increases lifespan of all four sir2;fob1;hstX(X = sirtuin) triple mutants [2558].
- References
-
- [2558] Tsuchiya et al. (2006) "Sirtuin-independent effects of nicotinamide on lifespan extension from calorie restriction in yeast." Aging Cell 5(6):505-514 (PubMed)
- [2309] Lamming et al. (2005) "HST2 mediates SIR2-independent life-span extension by calorie restriction." Science 309(5742):1861-1864 (PubMed)
In other databases
- GenAge model organism genes
- GenDR gene manipulations
- A homolog of this gene for Caenorhabditis elegans is present as sir-2.1
- CellAge
- A homolog of this gene for Homo sapiens is present as SIRT2
Homologs
- Caenorhabditis elegans
- sir-2.1
- Danio rerio
- sirt3
- Drosophila melanogaster
- Sirt2
- Homo sapiens
- SIRT2
- Mus musculus
- Sirt3
- Rattus norvegicus
- Sirt2
- Schizosaccharomyces pombe
- hst2
External links
- Saccharomyces Genome Database
- Search
- Ensembl
- Search
- Entrez Gene
- ID 856092
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar