GenDR Dietary Restriction Gene Manipulation: gig
Gene Information (Entrez Gene ID: 40201)
- Symbol
- gig
- Aliases
- 6975 C1 CG6975 Dmel\CG6975 dTsc2 dTSC2 gig|Tsc2 l(3)109 ME 109 tsc2 Tsc2 TSC2 Tsc2/gig
- Name
- gigas
- Organism
- Drosophila melanogaster (AnAge)
- Entrez Gene ID
- 40201
Potential relevance to dietary restriction and ageing
- Observations
-
Overexpression of gig (alias dTsc2) increased mean lifespan by 20% at 25 degree and protected mutants from deleterious effects of rich food, as if mimicking the effect of DR. Lifespan extension was dependent on concentration of yeast extract in the diet with no or slight life extension observed at low concentrations [1317]. Additionally, overexpression of gig (Tsc2) in mated females flies, which results in the inactivation of TOR signaling, affects lifespan extension by methionine restriction. While at 1.0x diet (normal level of all amino-acids, 15% dietary yeast) methionine reduction (from 1mM to 0.2mM) shortened lifespan both for Tsc2 overexpressing and control flies, at a 0.4x diet (0.4x reduced levels of all amino acids, corresponding to 6% dietary yeast) methionine reduction resulted in a decreased lifespan but only for the Tsc2 overexpressing flies, suggesting in this case that methionine reduction and overexpressing Tsc2 share some common mechanisms [3474].
- References
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In other databases
- GenAge model organism genes
- This gene is present as gig
- LongevityMap
- A homolog of this gene for Homo sapiens is present as TSC2
Homologs
External links
- FlyBase
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- Ensembl
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- Entrez Gene
- ID 40201
- Homologues
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- Internet
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