Drosophila melanogaster GenDR Dietary Restriction Gene Manipulation: Thor

Gene Information (Entrez Gene ID: 33569)

Symbol
Thor
Aliases
153432_at 43-BP 4e-bp 4e-BP 4E-BP 4E-BP1 4ebp 4eBP 4EBP anon-WO0172774.158 BcDNA.HL08053 BcDNA:HL08053 CG8846 CT8705 d4e-bp d4E-BP d4E-BP1 d4eBP d4EBP Dm 4E-BP Dmel\CG8846 dthor eIF4E-BP l(2)06270 l(2)k07736 l(2)k13517 Phas1 pp20 thor Thor/EIF4EBP
Name
CG8846-PA
Organism
Drosophila melanogaster (AnAge)
Entrez Gene ID
33569

Potential relevance to dietary restriction and ageing

Observations

Null mutation in Thor (alias d4E-BP) causes a significant decrease in longevity (-25% median lifespan in males) [2579]. Thor is upregulated on the protein level in a foxo-independent manner upon DR, while it is transcriptionally induced in a foxo-dependent fashion by starvation. Thor null mutants cancel out DR-induced lifespan extension, because mutants exhibit a diminished change in lifespan when nutrient conditions were varied. Ubiquitously expression of Thor rescued DR response in females and males. Ubiquitously overexpression of wild-type Thor causes no change under ad libitum, but an activated allele (with more than 3-fold increased binding activity to delF4E) significantly extends lifespan of females (weak allele) and females as well as males (strong allele). Mean lifespan is extended by 11 to 40%. Median lifespan of males and females is enhanced by 11 and 22%, respectively. Maximum lifespan is extended by 16 and 18% for males and females, respectively. Under DR (0.25% YE) there is no lifespan extension, beyond the effect of DR alone, in all (wild-type, weak and strong) Thor alleles [2547].

References

    In other databases

    GenAge model organism genes
    • This gene is present as Thor

    Homologs

    Danio rerio
    eif4ebp3
    Homo sapiens
    EIF4EBP3
    Mus musculus
    Eif4ebp3
    Rattus norvegicus
    Eif4ebp3

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    ID 33569
    Homologues
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    UniProt
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    Internet
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