GenDR Dietary Restriction Gene Manipulation: p53
Gene Information (Entrez Gene ID: 2768677)
- Symbol
- p53
- Aliases
- CG10873 CG31325 CG33336 D-p53 Dm-P53 Dmel\CG33336 dmp53 Dmp53 DmP53 DMP53 dp53 Dp53 prac
- Name
- CG33336 gene product from transcript CG33336-RB
- Organism
- Drosophila melanogaster (AnAge)
- Entrez Gene ID
- 2768677
Potential relevance to dietary restriction and ageing
- Observations
-
Overexpression of wild-type Dmp53 (alias p53) during adult life has no significant effect on lifespan. Expression of dominant negative form of Dmp53 specifically in neurons extends lifespan (58% in females and 32% in males) and increases resistance to oxidative stress. Dominant negative Dmp53 expression cancels lifespan extension effect of DR, low calorie-food (5 % SY) [1567].
- References
-
In other databases
- GenAge model organism genes
- This gene is present as p53
Homologs
No homologs found
External links
- FlyBase
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- Ensembl
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- Entrez Gene
- ID 2768677
- Homologues
- Search HomoloGene
- UniProt
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- Internet
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