Mus musculus GenDR Dietary Restriction Gene Manipulation: Ghr

Gene Information (Entrez Gene ID: 14600)

Symbol
Ghr
Aliases
GHBP GHR/BP
Name
Growth hormone receptor
Organism
Mus musculus (AnAge)
Entrez Gene ID
14600

Potential relevance to dietary restriction and ageing

Observations

Ghr knockout mice (GHRKO) are dwarfs with significantly extended lifespan by up to 40% [3]. DR (30%) fails to affect overall survival, average or median long-lifespan of GHRKO mice and increased maximal lifespan only in females. Insulin sensitivity in GHRKO mutants is greater than in wild-type and is not further increased by DR [1773]. Intermittent fasting also fails to extend the long lifespan of GHRKO mice [2583]. GHR-knockout mice live longer than wild-type mice when their diet contains 0.43% or 1.3% methionine. Contrastly, there is a minimal difference in lifespan on a diet of 0.16% methionine, wild-type mice being under these conditions long-lived as well [3476].

References

    In other databases

    GenAge model organism genes
    • This gene is present as Ghr
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as GHR
    GenDR gene expression
    • This gene is present as Ghr
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as GHR

    Homologs

    Danio rerio
    ghra
    Homo sapiens
    GHR
    Rattus norvegicus
    Ghr

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    ID 14600
    Homologues
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    UniProt
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    Internet
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