GenDR Dietary Restriction Gene Manipulation: Ghr
Gene Information (Entrez Gene ID: 14600)
- Symbol
- Ghr
- Aliases
- GHBP GHR/BP
- Name
- Growth hormone receptor
- Organism
- Mus musculus (AnAge)
- Entrez Gene ID
- 14600
Potential relevance to dietary restriction and ageing
- Observations
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Ghr knockout mice (GHRKO) are dwarfs with significantly extended lifespan by up to 40% [3]. DR (30%) fails to affect overall survival, average or median long-lifespan of GHRKO mice and increased maximal lifespan only in females. Insulin sensitivity in GHRKO mutants is greater than in wild-type and is not further increased by DR [1773]. Intermittent fasting also fails to extend the long lifespan of GHRKO mice [2583]. GHR-knockout mice live longer than wild-type mice when their diet contains 0.43% or 1.3% methionine. Contrastly, there is a minimal difference in lifespan on a diet of 0.16% methionine, wild-type mice being under these conditions long-lived as well [3476].
- References
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In other databases
- GenAge model organism genes
- This gene is present as Ghr
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as GHR
- GenDR gene expression
- This gene is present as Ghr
- LongevityMap
- A homolog of this gene for Homo sapiens is present as GHR
Homologs
External links
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- ID 14600
- Homologues
- Search HomoloGene
- UniProt
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- Internet
- Search Google or Search Google Scholar