GenDR Dietary Restriction Gene Manipulation: LAT1
Gene Information (Entrez Gene ID: 855653)
- Symbol
- LAT1
- Aliases
- ODP2 PDA2
- Name
- dihydrolipoyllysine-residue acetyltransferase
- Organism
- Saccharomyces cerevisiae (AnAge)
- Entrez Gene ID
- 855653
Potential relevance to dietary restriction and ageing
- Observations
-
LAT1 is suggested to play a role in lifespan extension of DR. Deleting LAT1 abolishes replicative lifespan extension induced by 0.5% and 0.05% glucose restriction. In contrast, overexpressing Lat1 extends replicative lifespan, and this lifespan extension was not further increased by 0.5% glucose restriction. Similar to DR, replicative lifespan extension by LAT1 overexpression largely requires mitochondrial respiration [2317]. Interestingly, LAT1 overexpression does not require the Sir2 family to extend lifespan. Lat1 is also a limiting longevity factor in non-dividing cells in that overexpressing LAT1 extends cell survival during prolonged culture at stationary phase.
- References
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In other databases
- GenAge model organism genes
Homologs
- Caenorhabditis elegans
- F23B12.5
- Danio rerio
- dlat
- Drosophila melanogaster
- CG5261
- Homo sapiens
- DLAT
- Mus musculus
- Dlat
- Rattus norvegicus
- uncharacterized_M0RA
- Schizosaccharomyces pombe
- lat1
External links
- Saccharomyces Genome Database
- Search
- Ensembl
- Search
- Entrez Gene
- ID 855653
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar