GenDR Dietary Restriction Gene Manipulation: trx-1
Gene Information (Entrez Gene ID: 181863)
Potential relevance to dietary restriction and ageing
- Observations
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Thioredoxins regulate many cellular redox processes. trx-1 is mainly associated with neurons and is expressed in ASJ ciliated sensory neurons and to some extent also on the posterior-most internal cells. trx-1 null mutant display reduced mean and maximum lifespan [2613]. trx-1 overexpression extends lifespan in wild-type but not in eat-2 mutants. trx-1 deletion completely suppresses the lifespan extension caused by eat-2 mutation, but only partially suppresses that by daf-2 mutations. Ectopic expression of trx-1 in ASJ neurons (but not in the intestine) in trx-1 mutants rescues the lifespan-extension conferred by eat-2 mutation. trx-1 deletion almost completely suppresses lifespan extension induced by dietary deprivation (DD). DD upregulates trx-1 expression in ASJ neurons. DR activates trx-1 in ASJ neurons which in turn triggers a trx-1-dependent non-cell autonomous mechanism to extend adult lifespan [2612].
- References
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In other databases
- GenAge model organism genes
Homologs
- Danio rerio
- txn
- Drosophila melanogaster
- TrxT
- Homo sapiens
- TXNDC8
- Mus musculus
- Txndc8
- Rattus norvegicus
- Txndc8
- Saccharomyces cerevisiae
- TRX3
- Schizosaccharomyces pombe
- trx1
External links
- WormBase
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- Ensembl
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- Entrez Gene
- ID 181863
- Homologues
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- UniProt
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- Internet
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