GenDR Dietary Restriction Gene Manipulation: FKH1
Gene Information (Entrez Gene ID: 854675)
- Symbol
- FKH1
- Name
- ForK head Homolog 1
- Organism
- Saccharomyces cerevisiae (AnAge)
- Entrez Gene ID
- 854675
Potential relevance to dietary restriction and ageing
- Observations
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Deletion of FKH1 or FKH2 has no effect on neither replicative, nor chronological lifespan [2556]. Deletion of both FKH1 and FKH2 reduces mean chronological lifespan by 50% and abrogates lifespan extension and increased stress resistance conferred from water starvation (extreme DR). Modest increase in FKH1 or FKH2 expression results in a slight increased chronological and replicative lifespan as well as stress resistance [2614].
- References
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Homologs
External links
- Saccharomyces Genome Database
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- Entrez Gene
- ID 854675
- Homologues
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