Saccharomyces cerevisiae GenDR Dietary Restriction Gene Manipulation: FKH1

Gene Information (Entrez Gene ID: 854675)

Symbol
FKH1
Name
ForK head Homolog 1
Organism
Saccharomyces cerevisiae (AnAge)
Entrez Gene ID
854675

Potential relevance to dietary restriction and ageing

Observations

Deletion of FKH1 or FKH2 has no effect on neither replicative, nor chronological lifespan [2556]. Deletion of both FKH1 and FKH2 reduces mean chronological lifespan by 50% and abrogates lifespan extension and increased stress resistance conferred from water starvation (extreme DR). Modest increase in FKH1 or FKH2 expression results in a slight increased chronological and replicative lifespan as well as stress resistance [2614].

References

    Homologs

    Drosophila melanogaster
    fd68A
    Mus musculus
    Foxk1

    External links

    Saccharomyces Genome Database
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    Ensembl
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    Entrez Gene
    ID 854675
    Homologues
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    UniProt
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    Internet
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