GenDR Dietary Restriction Gene Manipulation: TSA1
Gene Information (Entrez Gene ID: 854980)
- Symbol
- TSA1
- Aliases
- TPX1 ZRG14
- Name
- Thiol-Specific Antioxidant 1
- Organism
- Saccharomyces cerevisiae (AnAge)
- Entrez Gene ID
- 854980
Potential relevance to dietary restriction and ageing
- Observations
-
Disruption of TSA1 shortens chronological lifespan [2633]. Replicative lifespan extension by DR in sir2;fob1 double mutant is reduced by TSA1 deletion mutant. Wild-type cells require TSA1 to fully extend lifespan. Mutation in CDC35 (adenylate cyclase), a genetic mimetic of DR, is dependent on TSA1 to extend lifespan [2587].
- References
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In other databases
- GenAge model organism genes
- This gene is present as TSA1
Homologs
No homologs found
External links
- Saccharomyces Genome Database
- Search
- Ensembl
- Search
- Entrez Gene
- ID 854980
- Homologues
- Search HomoloGene
- UniProt
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- Internet
- Search Google or Search Google Scholar