Saccharomyces cerevisiae GenDR Dietary Restriction Gene Manipulation: SRX1

Gene Information (Entrez Gene ID: 853776)

Symbol
SRX1
Name
SulfiRedoXin 1
Organism
Saccharomyces cerevisiae (AnAge)
Entrez Gene ID
853776

Potential relevance to dietary restriction and ageing

Observations

Extra copy of SRX1 counteracts age-related hyperoxidation of Tsa1 and extends replicative lifespan by 15 - 20% in a TSA1-dependent manner. Replicative lifespan extension in sir2;fob1 double mutant by DR is reduced by SRX1 deletion. DR fails to further extend replicative lifespan of cells carrying an extra copy of SRX1. Mutation in CDC35 (adenylate cyclase), a genetic mimetic of DR, is dependent on SRX1 to extend replicative lifespan [2587].

References

    In other databases

    LongevityMap
    • A homolog of this gene for Homo sapiens is present as SRXN1

    Homologs

    Danio rerio
    srxn1
    Drosophila melanogaster
    CG6762
    Homo sapiens
    SRXN1
    Mus musculus
    Srxn1
    Schizosaccharomyces pombe
    srx1

    External links

    Saccharomyces Genome Database
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    Ensembl
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    Entrez Gene
    ID 853776
    Homologues
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    UniProt
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    Internet
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