GenDR Dietary Restriction Gene Manipulation: PKH2
Gene Information (Entrez Gene ID: 854053)
- Symbol
- PKH2
- Name
- Pkb-activating Kinase Homolog 2
- Organism
- Saccharomyces cerevisiae (AnAge)
- Entrez Gene ID
- 854053
Potential relevance to dietary restriction and ageing
- Observations
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PKH2 deletion increases replicative lifespan by 20% in the alpha strain and by 15% in the a strain [2504]. Deletion of PKH2 increases chronological lifespan by 29% [2632] to 34% [2593]. PKH2 mutation extends both replicative and chronological lifespan as well as cancels out DR-induced replicative and chronological lifespan extension [2581]. Mean and maximum replicative lifespan under ad libitum is extended by 38 and 69%, respectively.
- References
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In other databases
- GenAge model organism genes
- This gene is present as PKH2
Homologs
External links
- Saccharomyces Genome Database
- Search
- Ensembl
- Search
- Entrez Gene
- ID 854053
- Homologues
- Search HomoloGene
- UniProt
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- Internet
- Search Google or Search Google Scholar