GenDR Dietary Restriction Gene Manipulation: Akh
Gene Information (Entrez Gene ID: 38495)
- Symbol
- Akh
- Aliases
- akh AKH CG1171 dAkh Dmel\CG1171 Drm-AKH Hrth
- Name
- Adipokinetic hormone
- Organism
- Drosophila melanogaster (AnAge)
- Entrez Gene ID
- 38495
Potential relevance to dietary restriction and ageing
- Observations
-
Knockdown of Akh by RNAi does not by itself affect lifespan, but significantly inhibits DR-dependent increase in lifespan across a range of yeast concentrations in both females and males. While control females and males exhibit a 113%/22% increase in lifespan under DR, upon Akh inhibition there was a significant reduction in lifespan extension with DR (52%/5%). Besides, muscle-specific inhibition of Akh reduces the DR-dependent increase in lifespan. Akh inhibition also reduces the protective effect of DR on age-related decline in muscle function/activity. Overexpression of Akh enhances fat metabolism, spontaneous activity (148% on ad lib and 154% on DR), and lifespan on ad lib (33%). However, despite an increase in movement under DR, lifespan is not increased under a restricted diet [2597].
- References
-
Homologs
No homologs found
External links
- FlyBase
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- Entrez Gene
- ID 38495
- Homologues
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