GenDR Dietary Restriction Gene Manipulation: cha-1
Gene Information (Entrez Gene ID: 13192683)
- Symbol
- cha-1
- Name
- abnormal CHoline Acetyltransferase 1
- Organism
- Caenorhabditis elegans (AnAge)
- Entrez Gene ID
- 13192683
Potential relevance to dietary restriction and ageing
- Observations
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Mutation or RNA interference of cha-1 extends lifespan on killed or live bacteria as well as in liquid culture medium [2603]. cha-1(TY1652) mutation extends mean, 75%ile, and maximum lifespan by 23, 29, and 38%. The cha-1(PR1152) allele extends mean, 75%ile, and maximum lifespan by 22-49, 18-25, and 11-21%. Lifespan extension by cha-1 mutation is not abolished by daf-16 RNAi inactivation. eat-2 RNAi shortens the lifespan of cha-1 mutants [2603]. cha-1 participates in determining pharyngeal pumping rate to affect food intake [2620].
- References
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Homologs
- Drosophila melanogaster
- Cha
External links
- WormBase
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- Ensembl
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- Entrez Gene
- ID 13192683
- Homologues
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- Internet
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