GenDR Dietary Restriction Gene Manipulation: NDE1
Gene Information (Entrez Gene ID: 855176)
- Symbol
- NDE1
- Aliases
- NDH1
- Name
- NADH Dehydrogenase, External 1
- Organism
- Saccharomyces cerevisiae (AnAge)
- Entrez Gene ID
- 855176
Potential relevance to dietary restriction and ageing
- Observations
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Overexpression of NDE1 and NDE2 increases intracellular NAD/NADH ratio by lowering NADH concentration and increases replicative lifespan by 20-25%. This lifespan extension is non-additive with 0.5% glucose restriction [2329]. Deletion of NDE1 extends chronological lifespan [2330].
- References
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In other databases
- GenAge model organism genes
- This gene is present as NDE1
Homologs
No homologs found
External links
- Saccharomyces Genome Database
- Search
- Ensembl
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- Entrez Gene
- ID 855176
- Homologues
- Search HomoloGene
- UniProt
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- Internet
- Search Google or Search Google Scholar