GenDR Dietary Restriction Gene Manipulation: pnc-1
Gene Information (Entrez Gene ID: 176833)
- Symbol
- pnc-1
- Name
- Pyrazinamidase and NiCotinamidase
- Organism
- Caenorhabditis elegans (AnAge)
- Entrez Gene ID
- 176833
Potential relevance to dietary restriction and ageing
- Observations
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PNC-1 is a NAD+ salvage pathway enzyme, that is required for the lifespan-extension effect of dietary restricion. In PNC-1 null worms, the lifespan is extended by dietary restriction to a significantly smaller degree, and this effect was consistently observed at variuos degrees of restriction (from very mild to dietary deprivation). Contrastly, PNC-1 is not required for some of the healthspan benefits of dietary restriction. While pnc-1 mutants display a muscle function deficiency (shown by their rate of spontaneous body bending) compared to wild-type under ad libitum, dietary restriction comparably increases the frequency of bending in older wild-type and pnc-1 mutants. Additionally, thermotolerance, a measure which declines with age in C. elegans, is increased in both wild type and pnc-1 worms by dietary restriction.
- References
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In other databases
- GenAge model organism genes
- This gene is present as pnc-1
Homologs
- Schizosaccharomyces pombe
- pnc1
External links
- WormBase
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- Ensembl
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- Entrez Gene
- ID 176833
- Homologues
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- UniProt
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- Internet
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