GenDR Dietary Restriction Gene Manipulation: InR
Gene Information (Entrez Gene ID: 42549)
- Symbol
- InR
- Aliases
- 18402 CG18402 DIHR DILR dinr dInr dInR dINR DInr DInR dInsR dir dIR DIR Dir-a Dir-b DIRbeta dIRH DIRH Dmel\CG18402 er10 inr inR Inr INR Inr-alpha Inr-beta INS InsR insulin/insulin-like growth factor receptor IR l(3)05545 l(3)93Dj l(3)er10 lnR
- Name
- Insulin-like receptor
- Organism
- Drosophila melanogaster (AnAge)
- Entrez Gene ID
- 42549
Potential relevance to dietary restriction and ageing
- Observations
-
Overexpression of InRDN (the dominant negative form of insulin receptor) in mated females flies, which results in the inactivation of TOR signaling, affects lifespan extension by methionine restriction. While at 1.0x diet (normal level of all amino-acids, 15% dietary yeast) methionine reduction (from 1mM to 0.2mM) shortened lifespan both for InRDN overexpressing and control flies, at a 0.4x diet (0.4x reduced levels of all amino acids, corresponding to 6% dietary yeast) methionine reduction resulted in an increased lifespan but only for controls, suggesting in this case that methionine reduction and overexpressing InRDN share some common mechanisms.
- References
-
In other databases
- GenAge model organism genes
- GenDR gene manipulations
- A homolog of this gene for Caenorhabditis elegans is present as daf-2
Homologs
- Caenorhabditis elegans
- daf-2
- Danio rerio
- igf1rb
- Homo sapiens
- INSRR
- Mus musculus
- Insrr
- Rattus norvegicus
- Insrr
External links
- FlyBase
- Search
- Ensembl
- Search
- Entrez Gene
- ID 42549
- Homologues
- Search HomoloGene
- UniProt
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- Internet
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