GenDR Dietary Restriction Gene Manipulation: Pck1
Gene Information (Entrez Gene ID: 18534)
- Symbol
- Pck1
- Aliases
- PEPCK Pck-1 AI265463
- Name
- phosphoenolpyruvate carboxykinase 1, cytosolic
- Organism
- Mus musculus (AnAge)
- Entrez Gene ID
- 18534
Potential relevance to dietary restriction and ageing
- Observations
-
GH transgenic mice (overexpressing PCK1) are shorter lived when compared to wild-type controls. When methionine is severely restricted (0.16%), GH transgenic mice still live less than wild-type controls (39%), but their lifespans is about 50% greater than on a normal diet. On a less restrictive diet (0.43% methionine) or on an enriched diet (1.3% methionine) transgenic mice live significantly less than wild type controls (55-58%)
- References
-
In other databases
- GenAge model organism genes
- This gene is present as Pck1
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as PCK1
Homologs
- Caenorhabditis elegans
- pck-1
- Danio rerio
- pck1
- Drosophila melanogaster
- Pepck
- Homo sapiens
- PCK1
- Rattus norvegicus
- Pck1
External links
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- ID 18534
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar