GenDR Dietary Restriction Gene Manipulation: alh-6
Gene Information (Entrez Gene ID: 173510)
- Symbol
- alh-6
- Name
- ALdehyde deHydrogenase
- Organism
- Caenorhabditis elegans (AnAge)
- Entrez Gene ID
- 173510
Potential relevance to dietary restriction and ageing
- Observations
-
RNA interference or mutations in ALH-6 reduce lifespan of N2 wild-type worms by up to 40% in a diet-specific manner (when fed an E. coli OP50 diet, but not when fed HT115). Complementarily, and in a similar diet-dependent way, overexpression of ALH-6 extends N2 lifespan when on OP50. Additionally, in the eat-2 dietary restriction model, ALH-6 mutations complete abrogate the lifespan extension, suggesting that ALH-6 is required for the longevity effects of dietary restriction.
- References
In other databases
- GenAge model organism genes
- This gene is present as alh-6
Homologs
- Danio rerio
- aldh4a1
- Drosophila melanogaster
- P5CDh1
- Homo sapiens
- ALDH4A1
- Mus musculus
- Aldh4a1
- Rattus norvegicus
- Aldh4a1
- Saccharomyces cerevisiae
- PUT2
- Schizosaccharomyces pombe
- SPBC24C6.04
External links
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- ID 173510
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar