GenDR Dietary Restriction Gene Manipulation: fos-1
Gene Information (Entrez Gene ID: 178987)
- Symbol
- fos-1
- Name
- FOS (B-Zip transcription factor) homolog
- Organism
- Caenorhabditis elegans (AnAge)
- Entrez Gene ID
- 178987
Potential relevance to dietary restriction and ageing
- Observations
-
Post-developmental RNA interference of fos-1 reduces the lifespan extension of intermitent fasting. In the wild-type N2 worms, intermitent fasting increases lifespan by ~77%, while interference of fos-1 extends lifespan by only 36%. Moreover, contrastly, the lifespan of daf-2 mutants is unaffected by fos-1 RNA interference suggesting that fos-1 plays a role specifically in dietary restriction.
- References
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Homologs
No homologs found
External links
- WormBase
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- Ensembl
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- Entrez Gene
- ID 178987
- Homologues
- Search HomoloGene
- UniProt
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- Internet
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