GenDR Dietary Restriction Gene Manipulation: mlk-1
Gene Information (Entrez Gene ID: 178895)
- Symbol
- mlk-1
- Name
- human MLK (Mixed Lineage Kinase) homolog
- Organism
- Caenorhabditis elegans (AnAge)
- Entrez Gene ID
- 178895
Potential relevance to dietary restriction and ageing
- Observations
-
Loss-of-function mlk-1 mutant reduces the lifespan extension of intermitent fasting. In the wild-type N2 worms, intermitent fasting increases lifespan by ~77%, while in the mlk-1 mutants lifespan extension is reduced to ~50%.
- References
-
Homologs
- Danio rerio
- map3k9
- Homo sapiens
- MAP3K11
- Mus musculus
- Map3k11
- Rattus norvegicus
- Map3k11
- Schizosaccharomyces pombe
- cdc7
External links
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- ID 178895
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar