GenDR Dietary Restriction Gene Manipulation: NAT4
Gene Information (Entrez Gene ID: 855091)
- Symbol
- NAT4
- Aliases
- NAA40
- Name
- Nat4p
- Organism
- Saccharomyces cerevisiae (AnAge)
- Entrez Gene ID
- 855091
Potential relevance to dietary restriction and ageing
- Observations
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Under normal conditions downregulation of NAT4 in yeast increased mean replicative lifespan by 21%. When yeast cells lacking NAT4 were subjected to calorie restriction (0.1% glucose versus 2% glucose) no further lifespan extension was displayed, lifespan was comparable to wild type cells under calorie restriction and yeast cells lacking NAT4 under normal conditions. Thus downregulation of NAT4 triggers a dietary restriction like effect.
- References
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In other databases
- GenAge model organism genes
- This gene is present as NAT4
Homologs
- Schizosaccharomyces pombe
- SPCC825.04c
External links
- Saccharomyces Genome Database
- Search
- Ensembl
- Search
- Entrez Gene
- ID 855091
- Homologues
- Search HomoloGene
- UniProt
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- Internet
- Search Google or Search Google Scholar