GenDR Dietary Restriction Gene Manipulation: Hex-C
Gene Information (Entrez Gene ID: 44008)
- Symbol
- Hex-C
- Aliases
- CG8094 CT22069 DM2 Dmel\CG8094 Fk Hex HEX Hex-3 HEX-3 Hex-c HEX-C HexC Hk HK HK-C
- Name
- Hexokinase C
- Organism
- Drosophila melanogaster (AnAge)
- Entrez Gene ID
- 44008
Potential relevance to dietary restriction and ageing
- Observations
-
Under normal conditions downregulation of NAT4 in yeast increased mean replicative lifespan by 21%. When yeast cells lacking NAT4 were subjected to calorie restriction (0.1% glucose versus 2% glucose) no further lifespan extension was displayed, lifespan was comparable to wild type cells under calorie restriction and yeast cells lacking NAT4 under normal conditions. Thus downregulation of NAT4 triggers a dietary restriction like effect.
- References
-
In other databases
- GenAge model organism genes
- This gene is present as Hex-C
- GenDR gene expression
- A homolog of this gene for Mus musculus is present as Gck
Homologs
- Caenorhabditis elegans
- CELE_F14B4.2
- Danio rerio
- gck
- Homo sapiens
- GCK
- Mus musculus
- Gck
- Rattus norvegicus
- LOC100364027
- Schizosaccharomyces pombe
- hxk1
External links
- FlyBase
- Search
- Ensembl
- Search
- Entrez Gene
- ID 44008
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar