GenDR Dietary Restriction Gene Manipulation: Gdh
Gene Information (Entrez Gene ID: 42832)
- Symbol
- Gdh
- Aliases
- CG5320 DHE3 Dmel\CG5320 gdh GDH GLU-D Glud GLUD GLUD pre-mRNA
- Name
- Glutamate dehydrogenase
- Organism
- Drosophila melanogaster (AnAge)
- Entrez Gene ID
- 42832
Potential relevance to dietary restriction and ageing
- Observations
-
Wild type flies and flies containing mutant Gdh (71% activity compared to the wild type) were subjected to dietary restriction. Both wild type and mutant flies showed a significant increase in lifespan under dietary restriction compared to normal conditions. However, flies with mutant Gdh had a significantly longer lifespan (more than 14 days) than the wild type, demonstrating that decreased Gdh activity enhances the effects of dietary restriction.
- References
-
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as gdh-1
Homologs
- Caenorhabditis elegans
- gdh-1
- Danio rerio
- glud1a
- Homo sapiens
- GLUD2
- Mus musculus
- Glud1
- Rattus norvegicus
- Glud1
- Saccharomyces cerevisiae
- GDH1
- Schizosaccharomyces pombe
- gdh1
External links
- FlyBase
- Search
- Ensembl
- Search
- Entrez Gene
- ID 42832
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar