GenDR Dietary Restriction Gene Manipulation: Mdh2
Gene Information (Entrez Gene ID: 42185)
- Symbol
- Mdh2
- Aliases
- CG 7998 CG7998 Dmel\CG7998 l(3)psg7 Mdh MDH-2 mdh2 mMdh psg7
- Name
- Malate dehydrogenase 2
- Organism
- Drosophila melanogaster (AnAge)
- Entrez Gene ID
- 42185
Potential relevance to dietary restriction and ageing
- Observations
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Wild type flies and flies containing mutant Mdh2 (56% activity compared to the wild type) were subjected to dietary restriction. Both wild type and mutant flies showed a significant increase in lifespan under dietary restriction compared to normal conditions. However, flies with mutant Mdh2 had a significantly longer lifespan than the wild type, demonstrating that decreased Mdh2 activity enhances the effects of dietary restriction.
- References
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In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as mdh-2
Homologs
External links
- FlyBase
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- Ensembl
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- Entrez Gene
- ID 42185
- Homologues
- Search HomoloGene
- UniProt
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- Internet
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