GenDR Dietary Restriction Gene Manipulation: HXK2
Gene Information (Entrez Gene ID: 852639)
- Symbol
- HXK2
- Aliases
- HEX1 HKB SCI2
- Name
- HeXoKinase 2
- Organism
- Saccharomyces cerevisiae (AnAge)
- Entrez Gene ID
- 852639
Potential relevance to dietary restriction and ageing
- Observations
-
Deletion of HXK2 extends mean and maximum replicative lifespan by about 53% and 33%, respectively. Limiting glucose availability by mutating HXK2 significantly extends replicative lifespan and provides a genetic model of DR [2260]. HXK2 mutants have a transcriptional profile that significantly resembles DR cells [2274].
- References
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In other databases
- GenAge model organism genes
- This gene is present as HXK2
Homologs
- Caenorhabditis elegans
- CELE_Y77E11A.1
- Drosophila melanogaster
- Hex-t1
- Homo sapiens
- GCK
- Mus musculus
- Hk3
- Rattus norvegicus
- LOC100364027
External links
- Saccharomyces Genome Database
- Search
- Ensembl
- Search
- Entrez Gene
- ID 852639
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar