GenDR Dietary Restriction Gene Manipulation: HAP4
Gene Information (Entrez Gene ID: 853751)
- Symbol
- HAP4
- Name
- Heme Activator Protein 4
- Organism
- Saccharomyces cerevisiae (AnAge)
- Entrez Gene ID
- 853751
Potential relevance to dietary restriction and ageing
- Observations
-
Overexpression of HAP4 increases replicative lifespan, but is non-additive with 0.5% glucose restriction in lifespan extension. Lifespan extension by HAP4 overexpression requires SIR2 [2274]. HAP4 deletion suppresses replicative lifespan extension to 30% and 33% on 0.1% glucose and on elimination of non-essential amino acids, respectively [2638].
- References
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In other databases
- GenAge model organism genes
- This gene is present as HAP4
Homologs
No homologs found
External links
- Saccharomyces Genome Database
- Search
- Ensembl
- Search
- Entrez Gene
- ID 853751
- Homologues
- Search HomoloGene
- UniProt
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- Internet
- Search Google or Search Google Scholar