GenDR Dietary Restriction Gene Manipulation: PNC1
Gene Information (Entrez Gene ID: 852846)
- Symbol
- PNC1
- Name
- Pyrazinamidase/NiCotinamidase 1
- Organism
- Saccharomyces cerevisiae (AnAge)
- Entrez Gene ID
- 852846
Potential relevance to dietary restriction and ageing
- Observations
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Cells with 5 copies of PNC1 have a 70% longer replicative lifespan which is cancelled out by SIR2 deletion. PNC1 is upregulated under glucose DR [2499]. Deletion of PNC1 shortens replicative lifespan approximately by 10% [2499] and largely prevents replicative lifespan extension of 0.5% glucose restriction. 0.5% glucose restriction slightly extends median replicative lifespan (by 10 - 15%) but not maximum replicative lifespan in pnc1Delta [2329]. Increased expression of PNC1 is both necessary and sufficient for replicative lifespan extension by DR and low-intensity stress. DR does not further increase the lifespan of the 5XPNC1 strain [2499].
- References
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In other databases
- GenAge model organism genes
Homologs
External links
- Saccharomyces Genome Database
- Search
- Ensembl
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- Entrez Gene
- ID 852846
- Homologues
- Search HomoloGene
- UniProt
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- Internet
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