GenDR Dietary Restriction Gene Manipulation: daf-16
Gene Information (Entrez Gene ID: 172981)
- Symbol
- daf-16
- Name
- Abnormal DAuer Formation DAF-16, fork head-related transcription factor (daf-16)
- Organism
- Caenorhabditis elegans (AnAge)
- Entrez Gene ID
- 172981
Potential relevance to dietary restriction and ageing
- Observations
-
daf-16 is required for lifespan extension by mutation of daf-2 or age-1 [239]. In one experiment, daf-16 mutation suppressed lifespan extension by DR [2494]. Another study found that DR does not stimulate DAF-16 translocation to the nucleus, but daf-16 mutation cancels out the ability of DR to extend lifespan and to delay the decline in locomotor activity [2564]. In another study, DR by bacterial dilution extended lifespan of daf-16 mutants [2360]. daf-16 mutation decreases lifespan under ad lib, but fails to prevent bacterial dilution DR to further extend lifespan [2565]. Intermittent fasting-induced lifespan-extension is significantly diminished in null mutants of daf-16, suggesting daf-16 partially mediates intermittent fasting-induced longevity [2566]. daf-16 mutation cancels out the lifespan extension effect of solid DR and peptone dilution, regardless of the concentration of bacteria or peptones. Bacterial dilution DR significantly extends lifespan of daf-16 mutants, but to a lesser extent than that of wild-type. eat-2 mutation extends the lifespan of daf-16 mutants to the same extent than that of wild-type [2568]. Another study found that daf-16 RNAi completely blocks the lifespan extension by daf-2 mutation, but only partially by bacterial dilution DR [2569].
- References
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In other databases
- GenAge model organism genes
- This gene is present as daf-16
Homologs
- Danio rerio
- si:dkey-11f5.5
- Mus musculus
- Foxo6
External links
- WormBase
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- Ensembl
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- Entrez Gene
- ID 172981
- Homologues
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- UniProt
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- Internet
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