GenDR Dietary Restriction Gene Manipulation: clk-1
Gene Information (Entrez Gene ID: 175729)
- Symbol
- clk-1
- Name
- CLocK (biological timing) abnormality 1
- Organism
- Caenorhabditis elegans (AnAge)
- Entrez Gene ID
- 175729
Potential relevance to dietary restriction and ageing
- Observations
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Mutations in clk-1 slow down development and extend lifespan by 30% [946]. Food restriction by eat-2 mutation does not further extend the long lifespan of clk-1 mutant [1820]. DR and clk-1 mutations may extend lifespan by a similar process. DR by intermittent fasting significantly extends lifespan of clk-1 mutants, but to a lesser extent than that of wild-type [2566]. clk-1 mutants do not respond to solid DR-induced lifespan extension [2568]. clk-1 mutants have a decreased pharyngeal pumping that may provoke voluntary DR [1820].
- References
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In other databases
- GenAge model organism genes
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as COQ7
- LongevityMap
- A homolog of this gene for Homo sapiens is present as COQ7
Homologs
- Danio rerio
- zgc:158731
- Drosophila melanogaster
- COQ7
- Homo sapiens
- COQ7
- Mus musculus
- Coq7
- Rattus norvegicus
- Coq7
- Saccharomyces cerevisiae
- CAT5
- Schizosaccharomyces pombe
- coq7
External links
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- ID 175729
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar