GenDR Dietary Restriction Gene Manipulation: SCH9
Gene Information (Entrez Gene ID: 856612)
- Symbol
- SCH9
- Aliases
- HRM2 KOM1
- Name
- serine/threonine protein kinase SCH9
- Organism
- Saccharomyces cerevisiae (AnAge)
- Entrez Gene ID
- 856612
Potential relevance to dietary restriction and ageing
- Observations
-
Transposon-mediated mutagenesis of SCH9 increases resistance to oxidants and thermal stress as well as extends chronological lifespan by 30%. SCH9 deletion increases chronological lifespan by up to threefold. [2346]. Deletion of SCH9 also increases replicative lifespan by 18% (in DBY746) [2271]. SCH9 deletion increases the replicative lifespan by 40% in the alpha strain [2504]. The extended lifespan of SCH9 deletion mutants is not further extended by low glucose DR and is independent of Sir2 [1570]. Water restriction further increases chronological lifespan of sch9Delta [2556].
- References
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In other databases
- GenAge model organism genes
- This gene is present as SCH9
Homologs
- Schizosaccharomyces pombe
- sck1
External links
- Saccharomyces Genome Database
- Search
- Ensembl
- Search
- Entrez Gene
- ID 856612
- Homologues
- Search HomoloGene
- UniProt
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- Internet
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