GenDR Dietary Restriction Gene Manipulation: sams-1
Gene Information (Entrez Gene ID: 181370)
- Symbol
- sams-1
- Name
- S-Adenosyl Methionine Synthetase 1
- Organism
- Caenorhabditis elegans (AnAge)
- Entrez Gene ID
- 181370
Potential relevance to dietary restriction and ageing
- Observations
-
sams-1 RNAi significantly extends lifespan of wild-type by 14 - 15%, of daf-16 mutant by 30% and daf-2 by 55%, but fails to significantly further extend lifespan of eat-2 mutants. mRNA level of sams-1 is 2-fold reduced in eat-2 mutants. Like DR, sams-1 RNAi reduces brood size and slightly reproductive timing as well as causes a slender phenotype [2240].
- References
-
In other databases
- GenAge model organism genes
- This gene is present as sams-1
- GenDR gene expression
- A homolog of this gene for Mus musculus is present as Mat1a
Homologs
- Danio rerio
- mat2al
- Drosophila melanogaster
- Sam-S
- Homo sapiens
- MAT1A
- Mus musculus
- Mat1a
- Rattus norvegicus
- Mat1a
- Saccharomyces cerevisiae
- SAM2
- Schizosaccharomyces pombe
- sam1
External links
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- ID 181370
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar