GenDR Dietary Restriction Gene Manipulation: drr-2
Gene Information (Entrez Gene ID: 259546)
- Symbol
- drr-2
- Name
- Dietary Restriction Response (WT but not eat-2 lifespan increased) 2
- Organism
- Caenorhabditis elegans (AnAge)
- Entrez Gene ID
- 259546
Potential relevance to dietary restriction and ageing
- Observations
-
RNA interference of drr-2 extends lifespan [2236]. drr-2 RNAi extends lifespan of wild-type by 10-16%, but fails to significantly extend lifespan of daf-2 mutants or eat-2 mutants, a genetic model of DR. drr-2 RNAi keeps a normal, well-fed appearance and normal reproduction. drr-2 mRNA expression is 2-fold reduced in eat-2 mutants [2240]. drr-2 overexpression suppresses lifespan extension by eat-2 mutation and solid plate-based DR [2637].
- References
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In other databases
- GenAge model organism genes
- This gene is present as drr-2
Homologs
External links
- WormBase
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- Ensembl
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- Entrez Gene
- ID 259546
- Homologues
- Search HomoloGene
- UniProt
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- Internet
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