GenDR Dietary Restriction Gene Manipulation: pha-4
Gene Information (Entrez Gene ID: 180357)
- Symbol
- pha-4
- Name
- defective PHArynx development 4
- Organism
- Caenorhabditis elegans (AnAge)
- Entrez Gene ID
- 180357
Potential relevance to dietary restriction and ageing
- Observations
-
pha-4 is required for multiple forms of DR. RNAi of pha-4 decreases lifespan of wild-type worms and completely cancels out the lifespan extension of eat-2 mutants. Mutants of pha-4 do not respond to bacterial DR. Therefore, loss of pha-4 completely blocks the response to varying food concentration. Moreover, pha-4 expression is increased in response to DR. pha-4 overexpression increases longevity of wild-type only slightly, but significant that of daf-16 mutants [2340]. Intermittent fasting significantly extends lifespan of pha-4 [2566]. Solid DR extends lifespan of mutants with a temperature sensitive allele of pha-4 or pha-4 RNAi knockdown [2568]. PHA-4 appears to play a role in the life-extending effects of dietary restriction.
- References
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In other databases
- GenAge model organism genes
- This gene is present as pha-4
Homologs
External links
- WormBase
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- Ensembl
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- Entrez Gene
- ID 180357
- Homologues
- Search HomoloGene
- UniProt
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- Internet
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