GenDR Dietary Restriction Gene Manipulation: skn-1
Gene Information (Entrez Gene ID: 177343)
Potential relevance to dietary restriction and ageing
- Observations
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RNA interference or mutations in skn-1 prevent the life-extension effects of dietary restriction [2360]. skn-1 transgenes that overexpress a constitutive nuclear form of SKN-1 in the intestine extend the mean lifespan by 5-21% [2497]. skn-1 mutation does not alter lifespan under ad lib, but cancels out the lifespan extension effect of liquid DR or food variation at all. Ectopic expression of skn-1b in ASI neurons rescued liquid DR longevity defects of skn-1. Therefore, skn-1 might be regulated by nutritional stress [2360]. Intermittent fasting significantly extends lifespan of skn-1 mutants [2566]. Solid DR extends lifespan of a skn-1 loss-of-function mutant and wild-type to a similar extent [2568].
- References
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In other databases
- GenAge model organism genes
- This gene is present as skn-1
Homologs
No homologs found
External links
- WormBase
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- Ensembl
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- Entrez Gene
- ID 177343
- Homologues
- Search HomoloGene
- UniProt
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- Internet
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