GenDR Dietary Restriction Gene Manipulation: aak-2
Gene Information (Entrez Gene ID: 181727)
- Symbol
- aak-2
- Name
- AMP-Activated Kinase 2
- Organism
- Caenorhabditis elegans (AnAge)
- Entrez Gene ID
- 181727
Potential relevance to dietary restriction and ageing
- Observations
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AAK-2 could be a sensor that couples energy levels and insulin-like signals to lifespan. aak-2(ok524) knockout mutants have a 12% and 18% shorter mean and maximum lifespan, respectively as well as faster age-dependent accumulation of a lipofuscin-like fluorescent pigment in the intestine [2232]. Solid DR increases AMP:ATP ratio. aak-2 mutation suppresses lifespan extension and delay of the decline in locomotor activity resulting from solid DR. A constitutive active mutation of aak-2 is sufficient to cause increase stress resistance as well as to significantly extend lifespan. Both increased stress resistance and extended lifespan is reverted in daf-16 knockdown by RNAi [2564]. aak-2 mutation cancels out the lifespan extension effect of solid DR and peptone dilution, regardless of the concentration of bacteria or peptones. Bacterial dilution DR significantly extends lifespan of aak-2 mutants, but to a lesser extent than that of wild-type. eat-2 mutation extends the lifespan of aak-2 mutants to the same extent than that of wild-type.
- References
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In other databases
- GenAge model organism genes
Homologs
- Danio rerio
- prkaa2
- Drosophila melanogaster
- SNF1A
- Homo sapiens
- NIM1
- Mus musculus
- Prkaa1
- Rattus norvegicus
- Prkaa1
External links
- WormBase
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- Ensembl
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- Entrez Gene
- ID 181727
- Homologues
- Search HomoloGene
- UniProt
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- Internet
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