GenDR Dietary Restriction Gene Manipulation: hsp-12.6
Gene Information (Entrez Gene ID: 177778)
- Symbol
- hsp-12.6
- Name
- Heat Shock Protein
- Organism
- Caenorhabditis elegans (AnAge)
- Entrez Gene ID
- 177778
Potential relevance to dietary restriction and ageing
- Observations
-
hsp-12.6 loss-of-function mutation significantly extends lifespan under ad lib and significantly suppresses intermittent fasting-induced increase in lifespan, to a similar extend to that of daf-16 mutation. HSP-12.6 expression is induced by fasting in various tissues, including body wall muscle and neuronal systems. hsp-16.2 is one of downstream targets of DAF-16 in intermittent fasting-induced longevity. The extent of intermittent fasting-induced longevity in daf-16 hsp-12.6 double mutant is similar to that of single hsp-12.6 or daf-16 mutants [2566].
- References
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In other databases
- GenAge model organism genes
- This gene is present as hsp-12.6
Homologs
No homologs found
External links
- WormBase
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- Ensembl
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- Entrez Gene
- ID 177778
- Homologues
- Search HomoloGene
- UniProt
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- Internet
- Search Google or Search Google Scholar