GenDR Dietary Restriction Gene Manipulation: wwp-1
Gene Information (Entrez Gene ID: 171647)
- Symbol
- wwp-1
- Name
- WW domain Protein (E3 ubiquitin ligase) 1
- Organism
- Caenorhabditis elegans (AnAge)
- Entrez Gene ID
- 171647
Potential relevance to dietary restriction and ageing
- Observations
-
RNA interference of wwp-1 decreases median lifespan by 9% in wild-type animals and 24% in daf-2 mutants [2239]. Loss of wwp-1 function by RNAi or mutation reduces lifespan at 25 degree Celsius, but not 20 degree Celsius. wwp-1 overexpression extends lifespan by up to 20%. Reduced levels of wwp-1 completely suppress the extended longevity of eat-2 mutants. Lifespan of wwp-1 mutants across entire food concentration range by bacterial dilution in liquid culture or on solid plates does not noticeable change. There is no difference in wwp-1 mRNA levels under ad lib and DR [2572].
- References
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In other databases
- GenAge model organism genes
- This gene is present as wwp-1
Homologs
- Danio rerio
- wwp2
- Drosophila melanogaster
- Su(dx)
- Homo sapiens
- ITCH
- Mus musculus
- Itch
- Rattus norvegicus
- Itch
- Saccharomyces cerevisiae
- RSP5
- Schizosaccharomyces pombe
- pub1
External links
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- ID 171647
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar