GenDR Dietary Restriction Gene Manipulation: eat-2
Gene Information (Entrez Gene ID: 175072)
- Symbol
- eat-2
- Name
- EATing: abnormal pharyngeal pumping
- Organism
- Caenorhabditis elegans (AnAge)
- Entrez Gene ID
- 175072
Potential relevance to dietary restriction and ageing
- Observations
-
eat-2 mutants have reduced neuronal signalling due to the loss of the eat-2 nicotinic acetylcholine receptor resulting in decreased pharyngeal pumping that induces a DR-like state by restricting feeding. They are considered a genetic model of DR and live significant longer by up to 57 % [1820]. Solid DR further increases the long lifespan of eat-2 mutants [2568].
- References
-
In other databases
- GenAge model organism genes
- This gene is present as eat-2
Homologs
No homologs found
External links
- WormBase
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- Ensembl
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- Entrez Gene
- ID 175072
- Homologues
- Search HomoloGene
- UniProt
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- Internet
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