GenDR Dietary Restriction Gene Manipulation: Or83b
Gene Information (Entrez Gene ID: 40650)
- Symbol
- Or83b
- Aliases
- 83A.2 83b A45 CG10609 Dmel\CG10609 DOR45 DOR83b OR49 or83b Or83b OR83b OR83B vainsA
- Name
- Odorant receptor 83b
- Organism
- Drosophila melanogaster (AnAge)
- Entrez Gene ID
- 40650
Potential relevance to dietary restriction and ageing
- Observations
-
Loss-of-function mutation in Or83b results in olfactory defects, altered adult metabolism, enhanced stress resistance, and life-extension. Fully fed female homozygous Or83b null mutants exhibit a 56% increase in median lifespan and a 30% increase in maximum lifespan. Males are also significantly longer-lived, though to a smaller degree and maximum lifespan is not extended. Heterozygous mutants of both sexes show an intermediate longevity. Lifespan of homozygous Or83b null mutants is further increased by DR, but the relative increase in median and mean longevity is significantly greater when mutants were maintained in well-fed conditions [2337].
- References
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In other databases
- GenAge model organism genes
- This gene is present as Orco
Homologs
No homologs found
External links
- FlyBase
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- Ensembl
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- Entrez Gene
- ID 40650
- Homologues
- Search HomoloGene
- UniProt
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- Internet
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