GenDR Dietary Restriction Gene Manipulation: chico
Gene Information (Entrez Gene ID: 64880)
- Symbol
- chico
- Aliases
- anon-WO0078940.1 anon-WO0078940.4 BcDNA.GH11263 BcDNA:GH11263 CG5686 chic Chico CHICO dIRS Dmel\CG5686 fs(2)4 fs(2)ry4 IRS IRS/chico
- Name
- Insulin receptor substrate-1
- Organism
- Drosophila melanogaster (AnAge)
- Entrez Gene ID
- 64880
Potential relevance to dietary restriction and ageing
- Observations
-
Mutation in chico extends mean, median, and maximum lifespan by 56%, 48%, and 42% in homozygotes and 44%, 36%, and 35% in heterozygotes. chico mutation produces dwarf, long-lived females at normal nutrition. Male heterozygous live 13% longer than wild-type, but male homozygous have a shortened lifespan [188]. Wild-type and chico mutant females have similar peak lifespan under DR, but the food concentration at which these are achieved is shifted to higher amounts. chico mutation induces a state equivalent to submaximal, DR-induced slowing of aging [2576].
- References
-
In other databases
- GenAge model organism genes
- This gene is present as chico
Homologs
No homologs found
External links
- FlyBase
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- Ensembl
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- Entrez Gene
- ID 64880
- Homologues
- Search HomoloGene
- UniProt
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- Internet
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