DrugAge entry for Rifampicin

Name
Rifampicin 
Synonyms
13292-46-1 • 3-(((4-Methyl-1-piperazinyl)imino)methyl)rifamycin SV • Archidyn • Rifa • Rifadin • Rifadin I.V. • Rifadine • Rifagen • Rifaldazine • Rifampicin • Rifampicin SV • Rifampicina • Rifampicine • Rifampicinum • rifampin • Rifamycin AMP • Rifaprodin • Rifoldin • Rifoldine • Riforal • Rimactan • Rimactane • Rimactizid • Rimazid • Tubocin 
CAS Number
13292-46-1 
IUPAC Name
 
PubChem CID
5381226 
SEP-L1000 side effects
Adrenal insufficiency, Agranulocytosis, Anaemia, Anaphylactic shock, Asthenia, Ataxia, Body temperature increased, Bone pain, Cerebral haemorrhage, Chills, Colitis, Confusional state, Conjunctivitis, Decreased appetite, Diarrhoea, Disseminated intravascular coagulation, Dizziness, Dyspepsia, Dyspnoea, Enterocolitis, Eosinophilia, Erythema, Erythema multiforme, Face oedema, Fatigue, Flatulence, Flushing, Glossodynia, Haematuria, Haemoglobin decreased, Haemolysis, Haemolytic anaemia, Haemorrhage, Headache, Hepatic function abnormal, Hepatitis, Hypersensitivity, Hypoaesthesia, Immunosuppression, Influenza, Jaundice, Leukopenia, Liver function test abnormal, Muscle spasms, Muscular weakness, Myopathy, Nausea, Necrosis, Nephritis, Oedema, Oral pain, Pain, Pemphigoid, Pruritus, Pseudomembranous colitis, Psychotic disorder, Purpura, Rash, Renal failure, Renal failure acute, Renal tubular disorder, Renal tubular necrosis, Shock, Somnolence, Tenderness, Thrombocytopenia, Toxic epidermal necrolysis, Tubulointerstitial  

Summary

Species No. Entries MAX(Avg/Med Lifespan Change %) MEAN(Avg/Med Lifespan Change %) MAX(Max Lifespan Change %) MEAN(Max Lifespan Change %)

Results

Compound/Formulation Species Gender Strain Dosage Avg/Med Lifespan Change (%) Avg/Med Lifespan Significance Max Lifespan Change (%) Reference

Lifespan Charts for Rifampicin


References

Golegaonkar, S et al. (2015) Rifampicin reduces advanced glycation end products and activates DAF-16 to increase lifespan in Caenorhabditis elegans. Aging Cell 14(3)463-473 PubMed
Admasu, TD et al. (2018) Drug Synergy Slows Aging and Improves Healthspan through IGF and SREBP Lipid Signaling. Dev Cell 47(1)67-79.e5 PubMed

DGIdb Human Drug-Gene Interactions for Rifampicin

Interaction Types Gene Symbol Common Name HGNC Id DGIdb Sources References

Stitch DB Human Drug-Protein Interactions for Rifampicin

Up to 20 direct protein and drug interactions are displayed, having a medium confidence score (0.450) or above. Second order interactions are tabulated below.

Ensembl Id StringDB Id
s