LongevityMap variant
Entry Details
- Longevity Association
- Significant
- Population
- Italian (Central)
- Study Design
- Functional SNPs have been determined for 1071 unrelated healthy individuals (502 males and 569 females) from Central Italy, 18-106 years old, divided into three gender-specific age classes defined according to demographic information and accounting for the different survivals between sexes. The categories for men were: individuals <66 years old, individuals 66-88 years old, and individuals > 88 years old. The categories for women were: individuals <73 years old, individuals 73-91 years old, and individuals > 91 years old.
- Conclusions
- When comparing all 3 age groups, both two-loci and three-loci interaction are significantly associated with life-expectancy in males. For females, a significant two-loci interaction occurs in females between ADA 22G>A (rs73598374) and TNF-a 238G>A (rs361525) only when comparing young and mid-aged individuals.
- Identifier
- rs1800629
- In Other Studies (IDs)
- 2067 2664
- Cytogenetic Location
- 6p21.33
- UCSC Genome Browser
- View 6p21.33 on the UCSC genome browser
Gene details
- HGNC symbol
- TNF
- Aliases
- DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha
- Common name
- tumor necrosis factor
- Description
- This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 13
- OMIM
- 191160
- Ensembl
- ENSG00000232810
- UniProt/Swiss-Prot
- Q5STB3_HUMAN
- Entrez Gene
- 7124
- UniGene
- 241570
- HapMap
- View on HapMap
Homologs in model organisms
In other databases
- GenAge human genes
- This gene is present as TNF