LongevityMap variant
Entry Details
- Longevity Association
- Significant
- Population
- German
- Study Design
- V432L SNP was examined in 205 octogenarians and a reference group of 294 persons aged less than 80 years
- Conclusions
- In octogenarians, the 432L allele was significantly less prevalent than in the reference group
- Identifier
- V432L
- Cytogenetic Location
- 2p22.2
- UCSC Genome Browser
- View 2p22.2 on the UCSC genome browser
Gene details
- HGNC symbol
- CYP1B1
- Aliases
- CP1B; ASGD6; GLC3A; CYPIB1; P4501B1
- Common name
- cytochrome P450 family 1 subfamily B member 1
- Description
- This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 7
- OMIM
- 601771
- Ensembl
- ENSG00000138061
- UniProt/Swiss-Prot
- CP1B1_HUMAN
- Entrez Gene
- 1545
- UniGene
- 154654
- HapMap
- View on HapMap